Meta analysis of the effect of Lifeport and static cold storage on donor kidney Zhang Su,Chen Yanjun,Wang Cheng,Fu Shengjun,Yang Li.Institute ofUrology ofLanzhou University,Department ofUrology,the Second Hospital ofLanzhou University,Gansu Nephron﹣Urological Medical Clinical Center,Key Laboratory of Urological Diseases of Gansu Province,Lanzhou 730030,China / 器官移植

ABSTRACT

Objective To evaluate the effect of Lifeport and static cold storage (CS)on preservation of donor kidney. Methods Medline,Embase,Cochrane library,CBMdisc,China National Knowledge Infrastructure,Wanfang database and VIP database were searched by computer,and relevant clinical studies on the effect of Lifeport and CS on preservation of transplant kidney were collected,with the search period from database construction to December 31,2015. According to the inclusion and exclusion criteria,relevant references were selected,quality was evaluated,information was extracted,and risk of bias in the study was evaluated.In addition,Meta analysis was conducted using software Stata 12. Results A total of 16 studies were included with 5 randomized controlled trials (RCT)and 11 retrospective cohort studies (RCS).The results of Meta analysis showed thatcompared with Group CS,(1 )for total deceased donor (TDD), incidence of delayed graft function (DGF)decreased in Group Lifeport after transplantation,duration of DGF and average length of stay decreased,and 1﹣year survival rate of kidney increased after operation.The incidence of postoperative acute rejection (AR)and 1﹣year survival rate of patients were similar in two groups.(2)for donor after cardiac death (DCD)postoperative incidence of DGF and average length of stay decreased in Group Lifeport;there was no statistical significance in incidence of primary nonfunction (PNF)and AR,1﹣year survival rate of kidneys and patients between two groups.(3)for expanded criteria donor (ECD)postoperative incidence of PNF decreased and 1﹣year survival rate of kidney increased in Group Lifeport;there was no statistical significance in postoperative incidence of DGF and AR and 1﹣year survival rate of kidney between two groups. Conclusions Application of Lifeport in preservation of donor kidney has certain advantages. However,more high﹣quality studies should be further conducted to verify the study findings due to limited quantity and quality of the study.