Roles of long noncoding RNA in cerebral ischemia / 国际脑血管病杂志

ABSTRACT

Long noncoding RNA (lncRNA) is a kind of RNA whose length exceeds 200 nt,but lacks a complete open reading frame.It participates in many biological processes through a variety of regulation mechanisms of gene expression and is also related to the occurrence and development of many diseases.Studies have shown that the expression of lncRNA in brain tissue changes significantly during cerebral ischemia,and participates in the pathophysiological process of cerebral ischemia.This article reviews the roles of lncRNA in cerebral ischemia in recent years,hoping to provide new ideas and strategies for the prevention,diagnosis,and treatment of ischemic stroke in the future.