Clinical use of biomarkers in pediatric heart failure / 中华实用儿科临床杂志

ABSTRACT

Heart failure includes many biological courses,such as neurohormonal,inflammation,oxid-ative stress,extracellular matrix remodeling,myocyte injury,myocyte stress,et al.All of these courses have their specific biomarkers,which can be used to estimate the process of heart failure.It is difficult to estimate pediatric heart failure severity and stage objectively just with medical histories,symptoms and signs.So these clinical characteristics needed to link up with the biomarkers.At present,biomarkers are getting into more extensive use in heart failure,including early diagnosis,differential diagnosis,risk stratification,therapy guiding,prognostic indication and calculation of targeted therapeutic strategies,et al.This review puts emphasis on the clinical use of some important biomarkers in pediatric heart failure.