Efficacy of sotalol hydrochloride on supraventricular tachycardia after surgery in children with congenital heart / 中华实用儿科临床杂志

ABSTRACT

Objective To observe the efficacy of sotalol hydrochloride on supraventricular tachycardia after surgery in children with congenital heart disease(CHD).Methods Twenty-one cases were observed from Sep.2005 to Mar.2012 from Beijing Anzhen Hospital Affiliated to Capital Medical University,who had sotalol hydrochloride for supraventricular tachycardia after CHD surgery.All patients were divided into 3 groups according to different dosage of sotalol hydrochloride,group Ⅰ≤0.30 mg/(kg · dose),group Ⅱ0.31-0.80 mg/(kg · dose),group Ⅲ0.81-2.00 mg/(kg · dose).The efficacy,the heart rate (HR),systolic blood pressure (SBP),central venous pressure (CVP) were compared at different time.If bradycardia,long QT syndrome,torsade de pointes and other arrhythmia happened were observed.Results The efficacy were 16.7％,20.0％ and 100％ in group Ⅰ,group Ⅱ and group Ⅲ.The efficacy in group Ⅲ was the highest and there was statistical difference in 3 groups(P ＜0.05).The heart rate dropped separately 17.2％,21.5％,34.9％ in 3 groups and the HR in group Ⅲ was lower than group Ⅰ and group Ⅱ at different times,but it had statistically significant difference only at time of 8 hours after administration(P ＜ 0.05).The SBP and CVP dropped slightly and there was no statistical difference in SBP and CVP in 3 groups(all P ＞ 0.05).There were no bradycardia,long QT syndrome and torsade de pointes,etc.Conclusions Sotalol hydrochloride is a safe and effective drug with slight side effect on supraventricular tachycardia after CHD surgery.The higher the dose,the better the efficacy.