Comparison of fasting and non－fasting blood lipid levels in children in Tianjin / 中华实用儿科临床杂志

ABSTRACT

Objective To compare the difference between fasting blood lipids and non－fasting blood lipids in children in Tianjin,and to explore the feasibility of non－fasting blood lipids detection in children.Methods A total of 223 child patients were enrolled in Department of Pediatrics,the Second Hospital of Tianjin Medical University from January 2017 to February 2018,fasting and 1－6 h post－dining blood samples were collected from each patient.Total cholesterol (TC),triglyceride (TG),high－density lipoprotein cholesterol (HDL－C)and low－density lipoprotein cholesterol (LDL－C)were measured.Self－control methods were used.Wilcoxon signed rank test was used for statisti-cal analysis.Results Compared with fasting lipids,non－fasting TC increased with 0.02 mmol/L,TG increased with 0.01 mmol/L,HDL－C increased with 0.03 mmol/L,while LDL－C decreased with 0.01 mmol/L,but non－high－density lipoprotein cholesterol did not change.Among them,only the difference in HDL －C between the fasting and non－fasting was statistically significant (Z＝ －2.870,P＜0.05).The difference in the change rate of all indicators was ＜3%.According to the dyslipidemia group comparison,the differences in hypercholesterolemia (0.72 mmol/L, Z＝ －2.551,P＝0.011),hypertriglyceridemia (0.73 mmol/L,Z＝ －3. 846,P＜0.001),low high－density lipopro-tein cholesterolemia (－0.04 mmol/L,Z ＝ －8.625,P ＜0.001)and normal level HDL －C (0.1 mmol/L,Z ＝－5.040,P＜0.001)between non －fasting lipids and fasting blood lipids were statistically significant.Conclusions The change of children's blood lipid profile in fasting and non－fasting conditions is little.Lipid testing in children does not require fasting.Blood tests can be performed at any appropriate time point in the normal diet.