Clinical value of platelet parameters and fibrinogen level changes in stroke patients / 心血管康复医学杂志

ABSTRACT

Objective:To explore diagnostic and predictive value of platelet count (PLT),mean platelet volume (MPV),platelet distribution width (PDW) and fibrinogen (Fg) level for stroke.Methods:According to pathological pattern,a to-tal of 98 stroke patients were divided into cerebral infarction group (n＝43,including 23 cases with large size cerebral in-farction and 20 cases with lacunar infarction) and cerebral hemorrhage group (n＝45).Another 51 healthy subjects under-going physical examination simultaneously were enrolled as healthy control group.PLT,MPV,PDW and Fg level were measured and compared among three groups.Results:Compared with healthy control group,there were significant reduc-tion in PLT [ (217.86 ± 53.92)×109/L vs.(180.40 ± 32.81)×109/L vs.(174.09 ± 40.18)×109/L] and significant rise in MPV [ (8.03 ± 0.99)×10-15L vs.(9.59 ± 1.04)×10-15L vs.(8.91 ± 1.43)×10-15L],PDW [ (13.97 ± 1.22)% vs.(16.43 ± 1.07)% vs.(16.09 ± 0.97)%] and Fg level [ (3.17 ± 0.95) g/L vs.(5.01 ± 1.33) g/L vs.(4.91 ± 0.92) g/L] in cerebral infarction group and cerebral hemorrhage group,P＝0.001 all;Compared with cerebral infarc-tion group,there was significant reduction in MPV in cerebral hemorrhage group,P＝0.012.There were no significant difference in platelet parameters and Fg level between large size cerebral infarction group and lacunar infarction group,P＞0.05 all.Conclusion:Detection of PLT,MPV,PDW and Fg level possess good application value in diagnosis and prediction of stroke,which is worth extending.