Safety of benapril combined amlodipine on hypertension and its influence on plasm TC and TG levels / 心血管康复医学杂志

ABSTRACT

Objective:To explore safety of benapril combined amlodipine on hypertension and its influence on levels of plasm total cholesterol (TC) and triglyceride (TG).Methods:A total of 180 hypertensive patients treated in our hospital were selected,randomly and equally divided into amlodipine group and combined treatment group (received amlodipine combined benapril therapy ),both groups were continuously treated for one month.Therapeutic outcome and incidence of adverse reactions were compared between two groups.Results:After treatment,compared with amlo-dipine group,there were significant reductions in systolic blood pressure [(146.3 ± 11.9) mmHg vs.(133.4 ± 15.1) mm-Hg],diastolic blood pressure [(90.5 ± 5.9) mmHg vs.(81.4 ± 6.1) mmHg],heart rate [(85.4 ± 10.8) beats/min vs.(74.5 ± 12.6) beats/min],levels of plasm TC [(5.17 ± 1.75) mmol vs.(3.52 ± 1.85) mmol] and TG[(1.64 ± 0.14) mmol vs.(1.32 ± 0.32) mmol] in combined treatment group,P＝0.001 all.Total incidence rate of adverse reactions of combined treatment group was significantly lower than that of amlodipine group (3.3% vs.15.6%,P＝0.005).Conclu-sionBenapril combined amlodipine can significantly reduce heart rate,blood pressure and levels of plasm total cholesterol and triglyceride in hypertensive patients.It＇s safe and effective,which is worth extending.