Advance in biomarkers of neuromyelitis optica / 中华实验眼科杂志

ABSTRACT

Neuromyelitis optica ( NMO ) is an autoimmune, demyelinating disease of the central nervous system manifesting with optic neuritis and longitudinally extensive transverse myelitis. Aquaporin.4 ( AQP4 ) .IgG is currently regarded as a specific biomarker of NMO. Nevertheless,AQP4.IgG seronegativity in 10％-25％ of NMO patients suggests that there are several other factors involved in NMO immunopathogenesis. In this article,we reviewed current knowledge about biomarkers of NMO from AQP4, myelin.oligodendrocyte glycoprotein, AQP1 and glial fibrillary acidic protein,providing a new insight in the diagnosis of NMO.