Impact of sarcopenia on the risk of falls, osteoporosis, fractures, and all causes of death among elderly people: A Meta-analysis of prospective cohort studies / 中华临床营养杂志

ABSTRACT

Objective To explore the relationship between sarcopenia and the risks of falls, osteoporo-sis, fractures and all-cause mortality among elderly people. Methods This was a meta-analysis of prospective cohort studies. Databases of OVID/Medline, PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure ( CNKI) and Chinese WanFang Database were searched systematically according to the inclusion and exclusion criteria. The literatures related to the relationship between sarcopenia and falls, os-teoporosis, fractures and all-cause mortality among elderly people from January 1987 to June 2017 were identi-fied. The quality of the literature was evaluated by the risk assessment tool Newcastle-Ottawa Scale recommen-ded by the Cochrane. Meta-analysis was conducted by RevMan 5. 3 and Stata 12. 1 software. Results Totally 13 prospective cohort studies including 19 376 subjects and 3 190 outcome events were entered in meta-analysis. The relative risk ( RR) for comprehensive adverse outcome events among subjects with sarcopenia was 1. 64 times of non-sarcopenia subjects (95% CI=1. 51-1. 78, P<0. 000 01), and the RRs for fall, osteoporosis, fractures and all-cause mortality were 1. 60 (95% CI=1. 42-1. 81, P<0. 000 01), 4. 85 (95% CI=2. 18- 10. 79, P=0. 000 1), 1. 59 (95% CI=1. 40-1. 80, P<0. 000 01), 2. 08 (95% CI=1. 18-3. 69, P=0. 01) times of non-sarcopenia subjects respectively. Conclusion Sarcopenia increases the risk of falls, fractures, all-cause mortality and comprehensive adverse outcome significantly, suggesting that sarcopenia might be a pre-dictor for adverse outcomes among elderly people.