Analysis of blood lipid characteristics and related factors in early childhood systemic lupus erythematosus / 中华风湿病学杂志

ABSTRACT

Objective To explore the characteristics of lipid profile in children with systemic lupus erythematosus (SLE) and its risk factors.Methods A total of 225 untreated children with SLE were enrolled in this study.According to the values of low-density lipoprotein cholesterol (LDL-C),very low density lipoprotein cholesterol (VLDL-C),high-density lipoprotein cholesterol (HDL-C),totalglycerin (TG) and triglyceride (TG),they were grouped into LDL-C normal group and elevated group,VLDL-C normal group and elevated group,HDL-C normal group and lower group,TG normal group and elevated group,TC normal group and elevated group.We used x2 test,binary logistic regression and t-test to analyze the relationship between various lipid groups and clinical symptoms,laboratory tests,disease activity,hormones and complications.Results One hundred and eighty-five cases (82.22％) of children with SLE developed dyslipidemia,mainly manifested as increased LDL-C,VLDL-C,TG,TC levelsand decreased HDL-C level.There was a positive correlation between urea nitrogen and TG (r=0.257,P＜0.01),positive correlation with LDL-C (r=0.129,P＜0.05)and positive correlation with VLDL-C (r=0.225,P＜0.01).Albumin and TG (r=-0.464,P＜0.01),TC (r=-0.246,P＜0.01),LDL-C (r=-0.138,P＜0.05),VLDL-C (r=-0.426,P＜0.05) were negatively correlated.Urine protein level (2 h) was positively correlated with TG (r=0.257,P＜0.01).Systemic lupus erythematosus disease activity index (SLEDAI) was positively correlated with TG (r=0.597,P＜0.01),positively correlated with VLDL-C (r=0.565,P＜0.01) and negatively correlated with HDL-C (r=-0.324,P＜0.01).Complement C3 was negatively correlated with TG (r=-0.284,P＜0.01).The positive proportion of anti-dsDNA antibody [TG-increased group (58/89) was higher than TG normal group (70/136) (x2=4.1 16,P=0.042);TC normal group (112/186) was higher than TC-increased group (16/39) (x2=4.841,P=0.028);LDL-C elevated group (7/21) was higher than LDL-C normal group (121/204) (x2=5.240,P=0.022)].The proportion of coronary involvement events in the TG increased group (25/89) was higher than that in the TG positive group (17/136) (x2=8.612,P=0.003).The proportion of LN was higher in each dyslipidemia group [TG increased group (54/89) was higher than TG normal group (34/136) (x2=28.75,P＜0.01);TC increased group (23/39) was higher than TC normal group (65/186)(x2=7.816,P=0.005);LDL-C elevated group (14/21) was higher than LDL-C normal group (75/204) (x2=7,385,P=0.007);VLDL-C elevated group (12/17) was higher than the VLDL-C normal group (76/208) (x2=7.651,P=0.006)] (P＜0.05).Conclusion Children with SLE have significant dyslipidemia.A variety of factors are involved in children with SLE dyslipidemia.Dyslipidemia can cause multiple organ damage in children with SLE.