Your browser doesn't support javascript.
loading
Clinical outcomes of stereotactic body radiotherapy for spinal metastases from hepatocellular carcinoma
Radiation Oncology Journal ; : 217-225, 2015.
Artigo em Inglês | WPRIM | ID: wpr-73635
ABSTRACT

PURPOSE:

To investigate the outcomes of patients with spinal metastases from hepatocellular carcinoma (HCC), who were treated by stereotactic body radiotherapy (SBRT). MATERIALS AND

METHODS:

This retrospective study evaluated 23 patients who underwent SBRT from October 2008 to August 2012 for 36 spinal metastases from HCC. SBRT consisted of approximately 2 fractionation schedules, which were 18 to 40 Gy in 1 to 4 fractions for group A lesions (n = 15) and 50 Gy in 10 fractions for group B lesions (n = 21).

RESULTS:

The median follow-up period was 7 months (range, 2 to 16 months). Seven patients developed grade 1 or 2 gastrointestinal toxicity, and one developed grade 2 leucopenia. Compression fractures occurred in association with 25% of the lesions, with a median time to fracture of 2 months. Pain relief occurred in 92.3% and 68.4% of group A and B lesions, respectively. Radiologic response (complete and partial response) occurred in 80.0% and 61.9% of group A and B lesions, respectively. The estimated 1-year spinal-tumor progression-free survival rate was 78.5%. The median overall survival period and 1-year overall survival rate were 9 months (range, 2 to 16 months) and 25.7%, respectively.

CONCLUSION:

SBRT for spinal metastases from HCC is well tolerated and effective at providing pain relief and radiologic response. Because compression fractures develop at a high rate following SBRT for spinal metastases from primary HCC, careful follow up of the patient is required.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Agendamento de Consultas / Taxa de Sobrevida / Estudos Retrospectivos / Seguimentos / Radiocirurgia / Carcinoma Hepatocelular / Intervalo Livre de Doença / Fraturas por Compressão / Metástase Neoplásica Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Inglês Revista: Radiation Oncology Journal Ano de publicação: 2015 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Agendamento de Consultas / Taxa de Sobrevida / Estudos Retrospectivos / Seguimentos / Radiocirurgia / Carcinoma Hepatocelular / Intervalo Livre de Doença / Fraturas por Compressão / Metástase Neoplásica Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Humanos Idioma: Inglês Revista: Radiation Oncology Journal Ano de publicação: 2015 Tipo de documento: Artigo