Your browser doesn't support javascript.
loading
Family history and risk of coronary heart disease / 中华流行病学杂志
Chinese Journal of Epidemiology ; (12): 173-178, 2018.
Artigo em Chinês | WPRIM | ID: wpr-736460
ABSTRACT
Objective To evaluate the association of family history with risk of major coronary events (MCE) and ischemic heart disease (IHD).Methods After excluding participants with heart disease,stroke or cancer at baseline survey,a total of 485 784 participants from the China Kadoorie Biobank,who had no missing data on critical variables,were included in the analysis.Cox regression analysis was used to estimate the hazard ratios (HR) and 95%CI.Subgroup analyses were performed according to the baseline characteristics.Results During a median of 7.2 years of follow-up,we documented 3 934 incident cases of MCE and 24 537 cases of IHD.In multivariableadjusted models,family history was significantly associated with risk of MCE and IHD.The adjusted HRs (95%CI) were 1.41 (1.19-1.65) and 1.25 (1.18-1.33),respectively.History of disease among siblings was more strongly associated with early-onset MCE than parental history (HR=2.97,95%CI1.80-4.88).Moreover,the association of family history with MCE and IHD was stronger in persons who were overweight or obesive,and the association between family history and MEC was stronger in smokers.Conclusion This large-scale,prospective study indicated that family history was an independent risk factor for MCE and IHD in China.The intervention targeting major known lifestyle risk factors and the management of chronic diseases should be strengthened for Chinese population,especially for the individuals with family history were at high risk.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo de etiologia / Estudo observacional / Estudo prognóstico / Fatores de risco Idioma: Chinês Revista: Chinese Journal of Epidemiology Ano de publicação: 2018 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo de etiologia / Estudo observacional / Estudo prognóstico / Fatores de risco Idioma: Chinês Revista: Chinese Journal of Epidemiology Ano de publicação: 2018 Tipo de documento: Artigo