Diagnostic and epidemiological features of the first two HIV-2 indigenous infections in Hunan province / 中华流行病学杂志

ABSTRACT

Objective To study the diagnostic and epidemiological features of the first two HIV-2 indigenous cases in Hunan province.Methods Blood samples from two individuals with "HIV antibody indeterminate" and HIV-2 specific band showed by HIV-1/2 western blotting method,were repeatedly collected and detected under HIV 1 + 2 strip immunoassay and PCR,in Changsha city,Hunan province,through March to November,2017.An epidemiological survey was carried out at the same time.Results Our findings showed that the two cases were sex partners,without histories of sexual contact with foreigners and the source of infection was unknown.Results from the HIV 1 + 2 antibody confirmation test showed that they were "HIV-2 antibody positive".Through amplifying and sequencing the gag area of HIV-2 and BLAST,the similarity of HIV-2 strains presented as 98％.The results also showed that there were HIV-2 specific fragments in the two cases.Conclusion HIV-2 indigenous cases had never been reported in China.These cases had brought new challenge on prevention,diagnosis and treatment of HIV/AIDS in China.