Association between nuclear factor kappa-light-chain-enhancer of activated B cells genetic polymorphisms and HCV susceptibility among the Chinese population under high-risk / 中华流行病学杂志

ABSTRACT

Objective To explore the association between nuclear factor kappa-light-chainenhancer of activated genetic polymorphisms in B cells (NF-κB) and the HCV susceptibility,among the Chinese population.Methods A total of 1 679 participants were enrolled;including 503 drug users and 1 176 other participants at risk under the exposure for blood.By using the logistic regression analysis,related risk factors for HCV infection among subjects were analyzed.Two NF-κB pathway variants,NF-κB1 rs72696119 and REL rs13031237 were then genotyped by TaqMan assay method.Logistic regression analysis was performed to analyze the association between gene polymorphisms and the susceptibility on HCV.Results Among the drug users,women (OR=0.408,95％CI0.308-0.767) appeared to be associated with the decreased risk for HCV infection,while factors as drug injection (OR=8.817,95％CI5.577-13.937) and the duration of drug-intake ＞5.5 years (OR=2.891,95％CI1.824-4.583) were associated with the increased risk for HCV infection.Among the participants who had been exposed to blood,women (OR=3.431,95％ CI2.360-4.988) were associated with the increased risk for HCV infection,while the levels of education beyond elementary school (OR =0.613,95％ CI0.429-0.876) were associated with the decreased risk for HCV infection.Compared to the reference NF-κB1 rs72696119 CC genotype,the carriage of GG genotype was associated with an increased risk of susceptibility on HCV (OR=1.412,95％ CI1.035-1.927) among the total study population.Results from the interaction analysis showed that there was no interactive effects appeared between rs72696119 and route of infection,or between rs72696119 and gender among the total population under study (all P＞0.05).Conclusion NF-κB1 polymorphism rs72696119 and related factors seemed associated with the susceptibility to HCV infection among high-risk Chinese populations.