Indirect Particle Agglutination Antibody Testing for Early Diagnosis of Mycoplasma pneumoniae pneumonia in Children / 소아감염
Korean Journal of Pediatric Infectious Diseases
;
: 71-80, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-73672
ABSTRACT
OBJECTIVES:
Outbreaks of pneumonia caused by Mycoplasma pneumoniae (MP) occur every 3-4 years in Korea, most recently in 2011. The aim of our study was to determine the optimal time to perform indirect particle agglutination antibody assays to improve early diagnosis of MP pneumonia in children.METHODS:
A database of 206 pediatric patients treated for pneumonia at the Hanyang University Hospital from June to October 2011 was analyzed retrospectively for demographic characteristics and laboratory test results.RESULTS:
Among the 206 patients treated for pneumonia during the study period, there were 160 children (mean age, 5.44 years) diagnosed with MP pneumonia, who were studied further. The mean age of these MP pneumonia patients was 5.44 years. Antibody titers increased with increasing time between symptom onset and the collection of serum collection MP titers were or =1640 for those collected after 8.58 days; P or =1640. In 42 MP pneumonia patients in whom there was a four-fold or greater increase in titer between successive serum samples, the optimal cut-off time-point for distinguishing between the initial and second titer groups was 7.5 days after the onset of symptoms (sensitivity, 90.5%; specificity, 92.9%).CONCLUSIONS:
Negative MP antibody titers earlier than 8 days after the onset of symptoms in children with pneumonia may require repeating to confirm the diagnosis. This finding could optimize diagnosis and result in better therapeutic outcomes of MP pneumonia in children.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pneumonia
/
Pneumonia por Mycoplasma
/
Surtos de Doenças
/
Estudos Retrospectivos
/
Sensibilidade e Especificidade
/
Aglutinação
/
Diagnóstico Precoce
/
Coreia (Geográfico)
/
Mycoplasma
/
Mycoplasma pneumoniae
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo de rastreamento
Limite:
Criança
/
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Korean Journal of Pediatric Infectious Diseases
Ano de publicação:
2013
Tipo de documento:
Artigo
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