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Preparation of an adenovirus expressing cytosine deaminase and observat ion on its tumor-killing effect in vitro / 第二军医大学学报
Academic Journal of Second Military Medical University ; (12): 47-49, 2001.
Artigo em Chinês | WPRIM | ID: wpr-736799
ABSTRACT

Objective:

To prepare an adenovirus, Ad-CD, expressing bacterial cytosine deaminase(CD),and use it for tumor suicide gene therapy.

Methods:

We constructed a recomb ined adenoviral vector carrying CD or LacZ. 293 packaging cell was trans fected by the newly-constructed plasmid and generated the infectious virus. The n the adenovirus was used to infect C26 cell in vitro.

Results:

The growth of Ad-CD-infected cell was obviously surpressed after admini stration of 5-FC.

Conclusion:

CD gene carried by adenoviral vec tor is effective for tumor cell suicide gene therapy in vitro.
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Academic Journal of Second Military Medical University Ano de publicação: 2001 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Academic Journal of Second Military Medical University Ano de publicação: 2001 Tipo de documento: Artigo