Study on the pharmacolinetics,tissue distridution and excretion of nerve growsth factof in mice / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 65-67, 2001.
Artigo
em Chinês
| WPRIM
| ID: wpr-736803
ABSTRACT
Objective:
To study the pharmacokinetics,thissue distribution and secretion of nerve growth factor(NGF)in mice.Methods:
The conecntration of NGF in various body fluids and tissue were determined by isotope tracer combined SDSPAGE method.Results:
The plasma concenmtration-time curve was in accordance with the two-compartment pharmacokinetic model.The elimation half-life(t1/2β)was 3.1.The half-life of distribution(t1/2ka)was 5min.Tpeak was 25 min.AUC was 72.4 mg·kg-1·h-1.The concentrations of NGF were high in thyroid,blood,submaxillary glands,superior cervical ganglion,adrenasl and kidneys.Conclusion:
NGF has a wide distribution,high tissue concentrationa nd excrtet mainly through the urine.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Academic Journal of Second Military Medical University
Ano de publicação:
2001
Tipo de documento:
Artigo
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