Prediction of Alzheimer's Pathological Changes in Subjective Cognitive Decline Using the Self-report Questionnaire and Neuroimaging Biomarkers
Dementia and Neurocognitive Disorders
;
: 19-29, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-739212
ABSTRACT
BACKGROUND AND PURPOSE:
Subjective cognitive decline (SCD) may be the first symptomatic stage of Alzheimer's disease (AD). Hence, a screening tool to characterize the patients' complaints and assess the risk of AD is required. We investigated the SCD neuroimaging biomarker distributions and the relevance between the self-report questionnaire and Alzheimer's pathologic changes.METHODS:
Individuals aged 50 and above with consistent cognitive complaints without any objective cognitive impairments were eligible for the study. The newly developed questionnaire consisted of 2 parts; 10 questions translated from the ‘SCD-plus criteria’ and a Korean version of the cognitive failure questionnaire by Broadbent. All the subjects underwent physical examinations such as blood work, detailed neuropsychological tests, the self-report questionnaire, brain magnetic resonance imagings, and florbetaben positron emission tomography (PET) scans. Amyloid PET findings were interpreted using both visual rating and quantitative analysis. Group comparisons and association analysis were performed using SPSS (version 18.0).RESULTS:
A total of 31 participants with SCD completed the study and 25.8% showed positive amyloid depositions. The degree of periventricular white matter hyperintensities (WMH) and hippocampal atrophy were more severe in amyloid-positive SCDs compared to the amyloid-negative group. In the self-reported questionnaire, the ‘informant's report a decline’ and ‘symptom's onset after 65 years of age’ were associated with more Alzheimer's pathologic changes.CONCLUSIONS:
Amyloid-positive SCDs differed from amyloid-negative SCDs on WMH, hippocampal atrophy, and a few self-reported clinical features, which gave clues on the prediction of AD pathology.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Exame Físico
/
Atrofia
/
Encéfalo
/
Biomarcadores
/
Programas de Rastreamento
/
Transtornos Cognitivos
/
Placa Amiloide
/
Tomografia por Emissão de Pósitrons
/
Doença de Alzheimer
Tipo de estudo:
Estudo prognóstico
/
Estudo de rastreamento
Idioma:
Inglês
Revista:
Dementia and Neurocognitive Disorders
Ano de publicação:
2019
Tipo de documento:
Artigo
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