Beneficial aspect of dexmedetomidine as a postoperative sedative for cardiac surgery
Anesthesia and Pain Medicine
;
: 65-71, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-739428
ABSTRACT
BACKGROUND:
The aim of this study was to compare the clinical outcomes of the sedative, analgesic, and hemodynamic effects of dexmedetomidine and midazolam for sedation after coronary artery bypass grafting (CABG).METHODS:
The adult patients undergoing elective CABG surgery under general anesthesia were randomly assigned to the dexmedetomidine (DEX) and midazolam (MDZ) groups. From the time of the sternal closure, dexmedetomidine (0.5–0.7 μg/kg/h) was continuously administered (DEX group), and midazolam (0.03–0.1 mg/kg) was administered by bolus (MDZ group). To maintain the target sedation level (Richmond Agitation-Sedation Scale [RASS] range, −2 to −1) until extubation in the intensive care unit (ICU), continuous doses of dexmedetomidine were regulated and midazolam was administered intermittently. Sedation (RASS) and pain scores (visual analogue scale) and hemodynamic changes were recorded every two hours, until the end of the mechanical ventilation assistance after entering the ICU.RESULTS:
The mean of the fraction within the target sedation level in each patient's total sedation time was 41.0% in the DEX group and 20.7% in the MDZ group (P = 0.026). In the DEX group, the RASS (P < 0.001) and cardiac index were lower (P = 0.047) than those in the MDZ group, but the other hemodynamic parameters and pain scores were not different.CONCLUSIONS:
This study showed that post-operative infusion of dexmedetomidine maintained a stable sedation without side effects in patients who underwent CABG surgery.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Cuidados Pós-Operatórios
/
Respiração Artificial
/
Cirurgia Torácica
/
Midazolam
/
Ponte de Artéria Coronária
/
Sedação Consciente
/
Dexmedetomidina
/
Hemodinâmica
/
Unidades de Terapia Intensiva
/
Anestesia Geral
Limite:
Adulto
/
Humanos
Idioma:
Inglês
Revista:
Anesthesia and Pain Medicine
Ano de publicação:
2018
Tipo de documento:
Artigo
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