Improvement of Cell Cycle Lifespan and Genetic Damage Susceptibility of Human Mesenchymal Stem Cells by Hypoxic Priming
International Journal of Stem Cells
;
: 61-67, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-739921
ABSTRACT
Hypoxic culture is widely recognized as a method to efficiently expand human mesenchymal stem cells (MSCs) without loss of stem cell properties. However, the molecular basis of how hypoxia priming benefits MSC expansion remains unclear. We report that hypoxic priming markedly extends the cell cycle lifespan rather than augmenting the multipotency of MSC differentiation lineage. Hypoxic priming does not affect to chromosome damage but significantly attenuates the susceptibility of chromosome damage. Our results provide important evidence that multipotency of human MSCs by hypoxic priming is determined by cell cycle lifespan.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Células-Tronco
/
Envelhecimento
/
Ciclo Celular
/
Células-Tronco Mesenquimais
/
Hipóxia
/
Métodos
Limite:
Humanos
Idioma:
Inglês
Revista:
International Journal of Stem Cells
Ano de publicação:
2018
Tipo de documento:
Artigo
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