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The Pharmacological Inhibition of ERK5 Enhances Apoptosis in Acute Myeloid Leukemia Cells
International Journal of Stem Cells ; : 227-234, 2018.
Artigo em Inglês | WPRIM | ID: wpr-739924
ABSTRACT
Acute myeloid leukemia (AML) is a fatal hematological malignancy which is resistant to a variety of chemotherapy drugs. Extracellular signal-regulated kinase 5 (ERK5) plays a novel role in chemoresistance in some cancer cells and this pathway is a central mediator of cell survival and apoptotic regulation. The aim of this study was to investigate the effect of ERK5 inhibitor, XMD8-92, on proliferation and apoptosis in AML cell lines. Findings showed that XMD8-92 inhibited the activation of ERK5 by G-CSF and decreased the expression of c-Myc and Cyclin D1. The treatment of XMD8-92 reduced the phosphorylation of ERK5 leading to a distinct inhibition of cell proliferation and increased apoptosis in Kasumi-1 and HL-60 cells. Taken together, our study suggests that the inhibition of ERK5 by XMD8-92 can trigger apoptosis and inhibit proliferation in AMLs. Therefore, the inhibition of ERK5 may be an effective adjuvant in AML chemotherapy.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fosforilação / Leucemia Mieloide Aguda / Ciclo Celular / Linhagem Celular / Sobrevivência Celular / Fator Estimulador de Colônias de Granulócitos / Apoptose / Células HL-60 / Neoplasias Hematológicas / Ciclina D1 Limite: Humanos Idioma: Inglês Revista: International Journal of Stem Cells Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fosforilação / Leucemia Mieloide Aguda / Ciclo Celular / Linhagem Celular / Sobrevivência Celular / Fator Estimulador de Colônias de Granulócitos / Apoptose / Células HL-60 / Neoplasias Hematológicas / Ciclina D1 Limite: Humanos Idioma: Inglês Revista: International Journal of Stem Cells Ano de publicação: 2018 Tipo de documento: Artigo