Comparative Effects of Curcumin and Tetrahydrocurcumin on Dextran Sulfate Sodium-induced Colitis and Inflammatory Signaling in Mice
Journal of Cancer Prevention
;
: 18-24, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-740093
ABSTRACT
BACKGROUND:
Curcumin, a yellow ingredient of turmeric (Curcuma longa Linn, Zingiberaceae), has long been used in traditional folk medicine in the management of inflammatory disorders. Although curcumin has been reported to inhibit experimentally-induced colitis and carcinogenesis, the underlying molecular mechanisms remain largely unresolved.METHODS:
Murine colitis was induced by dextran sulfate sodium (DSS) which mimics inflammatory bowel disease. Curcumin or tetrahydrocurcumin was given orally (0.1 or 0.25 mmol/kg body weight daily) for 7 days before and together with DSS administration (3% in tap water). Collected colon tissue was used for histologic and biochemical analyses.RESULTS:
Administration of curcumin significantly attenuated the severity of DSS-induced colitis and the activation of NF-κB and STAT3 as well as expression of COX-2 and inducible nitric oxide synthase. In contrast to curcumin, its non-electrophilic analogue, tetrahydrocurcumin has much weaker inhibitory effects.CONCLUSIONS:
Intragastric administration of curcumin inhibited the experimentally induced murine colitis, which was associated with inhibition of pro-inflammatory signaling mediated by NF-κB and STAT3.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Peso Corporal
/
Doenças Inflamatórias Intestinais
/
Sulfato de Dextrana
/
Dextranos
/
Colite
/
Colo
/
Curcumina
/
Curcuma
/
Óxido Nítrico Sintase Tipo II
/
Carcinogênese
Limite:
Animais
Idioma:
Inglês
Revista:
Journal of Cancer Prevention
Ano de publicação:
2018
Tipo de documento:
Artigo
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