The Effect of Microbiota on Colon Carcinogenesis
Journal of Cancer Prevention
;
: 117-125, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-740108
ABSTRACT
Although genetic background is known to contribute to colon carcinogenesis, the exact etiology of the disease remains elusive. The organ’s extensive interaction with microbes necessitated research on the role of microbiota on development of colon cancer. In this review, we summarized the defense mechanism of colon from foreign organism, and germ-free animal models that have been employed to elucidate microbial effect. We also comprehensively discussed the metabolic property of microbiota such as butyrate production, facilitation of heme toxicity, bile acid transformation, and nitrate reduction that has been shown to contribute to the development of the tumor. Finally, up-to-date subjects such as the effect of age and gender on microbiota are briefly discussed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Bile
/
Butiratos
/
Ácidos e Sais Biliares
/
Colo
/
Neoplasias do Colo
/
Ácido Butírico
/
Modelos Animais
/
Carcinogênese
/
Microbiota
/
Patrimônio Genético
Idioma:
Inglês
Revista:
Journal of Cancer Prevention
Ano de publicação:
2018
Tipo de documento:
Artigo
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