Structural Characteristics of Seven IL-32 Variants
Immune Network
;
: e8-2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-740220
ABSTRACT
IL-32 exists as seven mRNA transcripts that can translate into distinct individual IL-32 variants with specific protein domains. These translated protein domains of IL-32 variants code for specific functions that allow for interaction with different molecules intracellularly or extracellularly. The longest variant is IL-32γ possessing 234 amino acid residues with all 11 protein domains, while the shortest variant is IL-32α possessing 131 amino acid residues with three of the protein domains. The first domain exists in 6 variants except IL-32δ variant, which has a distinct translation initiation codon due to mRNA splicing. The last eleventh domain is common domain for all seven IL-32 variants. Numerous studies in different fields, such as inflammation, autoimmunity, pathogen infection, and cancer biology, have claimed the specific biological activity of individual IL-32 variant despite the absence of sufficient data. There are 4 additional IL-32 variants without proper transcripts. In this review, the structural characteristics of seven IL-32 transcripts are described based on the specific protein domains.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Biologia
/
RNA Mensageiro
/
Autoimunidade
/
Estrutura Terciária de Proteína
/
Códon de Iniciação
/
Inflamação
Idioma:
Inglês
Revista:
Immune Network
Ano de publicação:
2019
Tipo de documento:
Artigo
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