Prevalence and Clinical Characteristics of Mupirocin-Resistant Staphylococcus aureus / 대한임상미생물학회지
Korean Journal of Clinical Microbiology
;
: 18-23, 2011.
Artigo
em Coreano
| WPRIM
| ID: wpr-74127
ABSTRACT
BACKGROUND:
Nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) is a known risk factor for nosocomialtransmission and infection. In an effort to mitigate this problem, topical mupirocin has been widely used for clearing nasal carriage of MRSA. However, mupirocin resistance has become a worldwide concern due to increased use of the antibiotic. The aims of this study were to evaluate the clinical characteristics and prevalence of mupirocin resistance among clinical isolates of staphylococci and to investigate antimicrobial susceptibility.METHODS:
A total of 175 S. aureus specimens recovered over a 4-month period from various body sites were tested for resistance to mupirocin and other antibiotics using the Vitek2 automated system. The presence of the mupA gene was assessed in isolates exhibiting resistance to mupirocin and in other selected organisms. The clinical characteristics of the isolates were also reviewed.RESULTS:
Of the 175 S. aureus isolates, 9.1% (16/175) were resistant to mupirocin, with 1.7% (3/175) having high-level resistance (HR) and 7.4% (13/175) having low-level resistance (LR). Patients with HR-mupirocin-resistant S. aureus had a longer duration of hospitalization (P=0.026). Of the 13 LR-mupirocin-resistant S. aureus strains, 11 had identical antibiogram patterns. The mupA gene was detected only among HR isolates.CONCLUSION:
The rate of mupirocin resistance in the S. aureus isolates was high. The spread of mupirocin-resistant S. aureus may be due to nosocomial infection.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Staphylococcus
/
Staphylococcus aureus
/
Resistência a Medicamentos
/
Testes de Sensibilidade Microbiana
/
Infecção Hospitalar
/
Prevalência
/
Fatores de Risco
/
Mupirocina
/
Colo
/
Staphylococcus aureus Resistente à Meticilina
Tipo de estudo:
Estudo de etiologia
/
Estudo de prevalência
/
Fatores de risco
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Clinical Microbiology
Ano de publicação:
2011
Tipo de documento:
Artigo
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