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Evaluation of Tumor Blood Flow Using Alternate Ascending/Descending Directional Navigation in Primary Brain Tumors: A Comparison Study with Dynamic Susceptibility Contrast Magnetic Resonance Imaging
Korean Journal of Radiology ; : 275-282, 2019.
Artigo em Inglês | WPRIM | ID: wpr-741399
ABSTRACT

OBJECTIVE:

Alternate ascending/descending directional navigation (ALADDIN) is a novel arterial spin labeling technique that does not require a separate spin preparation pulse. We sought to compare the normalized cerebral blood flow (nCBF) values obtained by ALADDIN and dynamic susceptibility contrast (DSC) perfusion magnetic resonance imaging (MRI) in patients with primary brain tumors. MATERIALS AND

METHODS:

Sixteen patients with primary brain tumors underwent MRI scans including contrast-enhanced T1-weighted imaging, DSC perfusion MRI, and ALADDIN. The nCBF values of normal gray matter (GM) and tumor areas were measured by both DSC perfusion MRI and ALADDIN, which were compared by the Wilcoxon signed rank test. Subgroup analyses according to pathology were performed with the Wilcoxon signed rank test.

RESULTS:

Higher mean nCBF values of GM regions in the bilateral frontal lobe, temporal lobe, and caudate were detected by ALADDIN than by DSC perfusion MRI (p <0.05). In terms of the mean or median nCBF values and the mean of the top 10% nCBF values from tumors, DSC perfusion MRI and ALADDIN did not statistically significantly differ either overall or in each tumor group.

CONCLUSION:

ALADDIN tended to detect higher nCBF values in normal GM, as well as higher perfusion portions of primary brain tumors, than did DSC perfusion MRI. We believe that the high perfusion signal on ALADDIN can be beneficial in lesion detection and characterization.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Perfusão / Lobo Temporal / Neoplasias Encefálicas / Imageamento por Ressonância Magnética / Circulação Cerebrovascular / Angiografia por Ressonância Magnética / Substância Cinzenta / Lobo Frontal / Glioma Limite: Humanos Idioma: Inglês Revista: Korean Journal of Radiology Ano de publicação: 2019 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Perfusão / Lobo Temporal / Neoplasias Encefálicas / Imageamento por Ressonância Magnética / Circulação Cerebrovascular / Angiografia por Ressonância Magnética / Substância Cinzenta / Lobo Frontal / Glioma Limite: Humanos Idioma: Inglês Revista: Korean Journal of Radiology Ano de publicação: 2019 Tipo de documento: Artigo