The Role of MicroRNAs in Oncogenesis and Progression of Prostate Cancer
Korean Journal of Urological Oncology
;
: 1-6, 2018.
Artigo
em Coreano
| WPRIM
| ID: wpr-741470
ABSTRACT
MicroRNAs (miRNAs) are small noncoding RNAs that target mRNA to reduce gene and protein expression by repressing their targets' translation or inducing mRNA degradation. They play fundamental roles in various cancers, including prostate cancer. Each single miRNA may regulate hundreds of genes, and a certain gene may serve as a target by multiple miRNAs. Hence, miRNAs modulate, cell cycle, apoptosis, epithelial-mesenchymal transition (EMT), and metastasis, etc. In this review, we will summarize the several miRNAs that may function as oncogenes and tumor suppressors. And we will describe the each miRNAs associated with cell cycle, apoptosis, EMT, and metastasis in prostate cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oncogenes
/
Próstata
/
Neoplasias da Próstata
/
RNA Mensageiro
/
Ciclo Celular
/
Apoptose
/
Estabilidade de RNA
/
MicroRNAs
/
Pequeno RNA não Traduzido
/
Transição Epitelial-Mesenquimal
Idioma:
Coreano
Revista:
Korean Journal of Urological Oncology
Ano de publicação:
2018
Tipo de documento:
Artigo
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