Effect of bisphosphonate on temporomandibular joint in osteopenia-induced rats by botulinum toxin A injection on masticatory muscle: a preliminary study / 대한악안면성형재건외과학회지
Maxillofacial Plastic and Reconstructive Surgery
; : 11-2019.
Article
em En
| WPRIM
| ID: wpr-741583
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Botulinum toxin injection on the masticatory muscle induces the osteopenic condition on the ipsilateral condyle. Bisphosphonate suppresses bone resorption and is used to treat osteopenic or osteoporotic condition. This study aimed to evaluate the effect of bisphosphonate administration on prevention of condylar resorption and botulinum toxin A-induced disuse osteopenia in rats. RESULTS: The volume of the condyle and bone volume/tissue volume (BV/TV, %) showed a strong tendency towards statistical significance (p = 0.052 and 0.058). Trabecular thickness (Tb.Th, mm) and trabecular number (Tb.N, 1/mm) were significantly smaller in the Botox group than in the other groups (p < 0.05). The volume of the condyle and BV/TV in the bisphosphonate 100 and bisphosphonate 200 groups showed similar values when compared with the control group. CONCLUSION: Bisphosphonate administration after botulinum toxin A injection in the masticatory muscles appears to prevent condyle resorption and botulinum toxin-induced disuse osteopenia in rats.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Articulação Temporomandibular
/
Doenças Ósseas Metabólicas
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Reabsorção Óssea
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Toxinas Botulínicas
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Côndilo Mandibular
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Músculos da Mastigação
Limite:
Animals
Idioma:
En
Revista:
Maxillofacial Plastic and Reconstructive Surgery
Ano de publicação:
2019
Tipo de documento:
Article