A Conformational Isomer of Soulattrolide from the Stem Bark of Calophyllum symingtonianum and Its Antibacterial Activity
Natural Product Sciences
;
: 47-53, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-741597
ABSTRACT
Callophylum symingtonianum (Guttiferae), an evergreen broad-leaved tree that usually grows in hill forests, can be found distributed in the Malay Peninsula. The barks, leaves, flowers and seeds is often used medicinally to treat diarrhea and rheumatism. In the present study, we isolated two inophyllum type coumarins, 12-O-ethylinophyllum D (1) and iso-soulattrolide (2) from the stembarks of C. symingtonianum together with their antibacterial activity. The compounds were isolated by chromatographic methods on a silica gel. The structures were established by spectroscopic methods including UV, IR, (1D and 2D) NMR and mass spectrometry as well as by comparison with several literature sources. The antibacterial activity of those compounds was tested using a disc-diffusion assay against Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa. Both compound exhibited mild inhibition against P. aeruginosa with both 111 µg/ml MIC value. Compound 2 also inhibits S. aureus with 25 µg/ml MIC value.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pseudomonas aeruginosa
/
Espectrometria de Massas
/
Staphylococcus aureus
/
Bacillus cereus
/
Árvores
/
Florestas
/
Doenças Reumáticas
/
Cumarínicos
/
Calophyllum
/
Flores
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Natural Product Sciences
Ano de publicação:
2018
Tipo de documento:
Artigo
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