Ameliorative Effects of Ombuoside on Dopamine Biosynthesis in PC12 Cells
Natural Product Sciences
;
: 99-102, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-741610
ABSTRACT
This study investigated the effects of ombuoside, a flavonol glycoside, on dopamine biosynthesis in PC12 cells. Ombuoside at concentrations of 1, 5, and 10 µM increased intracellular dopamine levels at 1 – 24 h. Ombuoside (1, 5, and 10 µM) also significantly increased the phosphorylation of tyrosine hydroxylase (TH) (Ser40) and cyclic AMP-response element binding protein (CREB) (Ser133) at 0.5 – 6 h. In addition, ombuoside (1, 5, and 10 µM) combined with L-DOPA (20, 100, and 200 µM) further increased intracellular dopamine levels for 24 h compared to L-DOPA alone. These results suggest that ombuoside regulates dopamine biosynthesis by modulating TH and CREB activation in PC12 cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosforilação
/
Tirosina 3-Mono-Oxigenase
/
Proteínas de Transporte
/
Dopamina
/
Levodopa
/
Células PC12
Limite:
Animais
Idioma:
Inglês
Revista:
Natural Product Sciences
Ano de publicação:
2018
Tipo de documento:
Artigo
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