Estrogenic Activity of Sanguiin H-6 through Activation of Estrogen Receptor α Coactivator-binding Site
Natural Product Sciences
;
: 28-33, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-741648
ABSTRACT
A popular approach for the study of estrogen receptor α inhibition is to investigate the protein-protein interaction between the estrogen receptor (ER) and the coactivator surface. In our study, we investigated phytochemicals from Rubus coreanus that were able to disrupt ERα and coactivator interaction with an ERα antagonist. The E-screen assay and molecular docking analysis were performed to evaluate the effects of the estrogenic activity of R. coreanus extract and its constituents on the MCF-7 human breast cancer cell line. At 100 µg/mL, R. coreanus extract significantly stimulated cell proliferation (574.57 ± 8.56%). Sanguiin H6, which was isolated from R. coreanus, demonstrated the strongest affinity for the ERα coactivator-binding site in molecular docking analysis, with a binding energy of
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias da Mama
/
Linhagem Celular
/
Proliferação de Células
/
Estrogênios
/
Simulação de Acoplamento Molecular
/
Compostos Fitoquímicos
/
Rubus
Limite:
Humanos
Idioma:
Inglês
Revista:
Natural Product Sciences
Ano de publicação:
2019
Tipo de documento:
Artigo
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