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Impact of Single Dose Praziquantel Treatment on Schistosoma haematobium Infection among School Children in an Endemic Nigerian Community
The Korean Journal of Parasitology ; : 577-581, 2018.
Artigo em Inglês | WPRIM | ID: wpr-742294
ABSTRACT
Schistosomiasis is prevalent in Nigeria, and the foremost pathogen is Schistosoma haematobium, which affects about 29 million people. Single dose of the drug praziquantel is often recommended for treatment but the efficacy has not been documented in certain regions. Therefore, this study was designed to assess the impact of single dose praziquantel treatment on S. haematobium infection among school children in an endemic community of South-Western Nigeria. Urine samples were collected from 434 school children and 10 ml was filtered through Nucleopore filter paper before examination for egg outputs by microscopy. The prevalence was 24.9% at pre-treatment. There was no statistically significant difference for the prevalence of infection between males (14.7%) and females (10.2%), although the mean egg count for the females (9.87) was significantly more (P < 0.05) than the males (6.06). At 6 and 12 months post-treatment there was 74.4% and 86.4% reduction in the mean egg count, respectively. Interestingly, an increased prevalence of infection from 2.1% at 6 months to 7.7% at 12 months post-treatment was observed, nonetheless the mean egg count was reduced to 0.27 at 12th month from 1.98 at 6 months post-treatment. Resurgence in the prevalence rate between 6 and 12 months post-treatment with praziquantel is herein reported and the need for a follow-up treatment in endemic areas for adequate impact on schistosomiasis control is discussed.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Óvulo / Praziquantel / Schistosoma / Schistosoma haematobium / Esquistossomose / Prevalência / Seguimentos / Microscopia / Nigéria Tipo de estudo: Estudo observacional / Estudo de prevalência / Estudo prognóstico / Fatores de risco Limite: Criança / Feminino / Humanos / Masculino País/Região como assunto: África Idioma: Inglês Revista: The Korean Journal of Parasitology Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Óvulo / Praziquantel / Schistosoma / Schistosoma haematobium / Esquistossomose / Prevalência / Seguimentos / Microscopia / Nigéria Tipo de estudo: Estudo observacional / Estudo de prevalência / Estudo prognóstico / Fatores de risco Limite: Criança / Feminino / Humanos / Masculino País/Região como assunto: África Idioma: Inglês Revista: The Korean Journal of Parasitology Ano de publicação: 2018 Tipo de documento: Artigo