Understanding the pharmacokinetics of prodrug and metabolite
Translational and Clinical Pharmacology
;
: 1-5, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-742398
ABSTRACT
This tutorial explains the pharmacokinetics of a prodrug and its active metabolite (or parent drug) using a two-step, consecutive, first-order irreversible reaction as a basic model for prodrug metabolism. In this model, the prodrug is metabolized and produces the parent drug, which is subsequently eliminated. The mathematical expressions for pharmacokinetic parameters were derived step by step. In addition, we visualized these expressions to help understand the relationship between pharmacokinetic parameters easily. For the elimination rate-limited and formation rate-limited metabolism, we analyzed the plasma drug concentration versus time curve of a prodrug administered intravenously.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pais
/
Plasma
/
Farmacocinética
/
Metabolismo
Limite:
Humanos
Idioma:
Inglês
Revista:
Translational and Clinical Pharmacology
Ano de publicação:
2018
Tipo de documento:
Artigo
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