Pharmacodynamic principles and the time course of delayed and cumulative drug effects
Translational and Clinical Pharmacology
;
: 56-59, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-742406
ABSTRACT
This tutorial reviews the principles of the concentration — effect relationship for the usual case when drug effects are delayed relative to changes in circulating concentrations. The key processes determining delay are distribution from the circulation to the receptor, binding to the receptor to produce a stimulus and translation of the receptor stimulus into an effect through turnover of physiological mediators. Some clinical outcomes are dependent on the accumulation of drug action which is predictable in terms of basic pharmacokinetic and pharmacodynamic concepts.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Relação Dose-Resposta a Droga
/
Modelos Biológicos
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Translational and Clinical Pharmacology
Ano de publicação:
2018
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS