Regulation Mechanism of Long Noncoding RNAs in Colon Cancer Development and Progression
Yonsei Medical Journal
;
: 319-325, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-742552
ABSTRACT
Colorectal cancer (CRC) is the second most common cause of cancer-related death worldwide, and its high rates of relapse and metastasis are associated with a poor prognosis. Despite extensive research, the underlying regulatory mechanisms of CRC remain unclear. Long noncoding RNAs (lncRNAs) are a major type of noncoding RNAs that have received increasing attention in the past few years, and studies have shown that they play a role in many biological processes in CRC. Here, we summarize recent studies on lncRNAs associated with CRC and the signaling pathways and mechanisms underlying this association. We show that dysregulated lncRNAs may be new prognostic and diagnostic biomarkers or therapeutic targets for clinical application. This review contributes not only to our understanding of CRC, but also suggests novel signaling pathways associated with lncRNAs that can be targeted to block or eradicate CRC.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Recidiva
/
Fenômenos Biológicos
/
Biomarcadores
/
Neoplasias Colorretais
/
Colo
/
Neoplasias do Colo
/
RNA não Traduzido
/
RNA Longo não Codificante
/
Metástase Neoplásica
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Yonsei Medical Journal
Ano de publicação:
2019
Tipo de documento:
Artigo
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