Study on the relationship between HSPB1 gene expression and radiosensitivity sensitivity based on survival analysis model / 安徽医科大学学报

ABSTRACT

Objective To investigate the relationship between the expression level of heat shock protein B1 (HSPB1) and radiotherapy. Methods We used the gastric cancer data from TCGA. The data was randomly splited to two parts,one as testing data,another one as validation data. Results The results showed that the expression did not associate with overall survival,both on testing and validation data. For patients with high expression of HSPB1,there was no significant different between radiotherapy and nonradiotherapy group. The adjusted HR were 1. 08(0. 38 ～ 3. 09) and 1. 38(0. 53 ～ 3. 64),with P values 0. 89 and 0. 51 for testing and validation data,respectively. Interestingly,for patients with low expression of HSPB1,significant different between radiotherapy and nonradiotherapy group was observed. The adjusted HR were 0. 22(0. 06 ～ 0. 81) and 0. 03(0. 003 ～ 0. 220),with P values 0. 02 and 1. 07 × 10 - 3 for testing and validation data,respectively. Conclusion These results suggest that low expression of HSPB1 strongly associates with radiosensitivity. The survival rate of patients with low expression of HSPB1 after radiotherapy is significantly increased,suggesting that HSPB1 may be a potential molecular marker for precision radiotherapy of gastric cancer.