Study on mitochondrial DNA mutation in patients with primary multiple myeloma / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
;
(12): 88-90, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-742760
ABSTRACT
Objective To study the mitochondrial DNA mutation in patients with primary multiple myeloma. Methods The mitochondrial DNA of 5 patients with primary multiple myeloma in the First Hospital of Qinhuangdao from February to June 2017 were amplified by polymerase chain reaction (PCR) and sequenced directly, and the results were compared with revised Cambridge Reference Sequence (rCRS) and Human Mitochondrial Gene Database (mtDB) database. Results There were 42 mutation genes, with 52.38%(22/42) mutation genes in D-loop region, 9.52%(4/42) mutation genes in ND4L region, 2.38%(1/42) mutation genes in ND5 region, 26.19% (11/42) mutation genes in Cytb region, 7.14% (3/42) mutation genes in ND1 region, and 4.76% (2/42) mutation genes in COⅡ region. Conclusion There is a high mitochondrial DNA mutation rate in patients with primary multiple myeloma.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Leukemia & Lymphoma
Ano de publicação:
2019
Tipo de documento:
Artigo
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