The research progress of soluble fibrinogen-like protein 2 / 国际检验医学杂志
International Journal of Laboratory Medicine
;
(12): 468-471,507, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-742947
ABSTRACT
Soluble fibrinogen-like protein 2 (sFGL2) , is an novel effector secreted by the CD4+CD25+CD127lowTregs cells and plays an important role in immunoregulation.It is critical for the maintenance of the activity and function of Tregs.It can induce the apoptosis of B cells, suppress the maturation of dendritic cells and suppress the activation and proliferation of T cells through the FcγRⅡB receptor.This review concluded the recent progress of the genes, structure, immunoregulatory effects of sFGL2, and discussed the clinical implications of sFGL2in hepatitis, autoimmunity, transplantation, tumors and atherosclerosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
International Journal of Laboratory Medicine
Ano de publicação:
2019
Tipo de documento:
Artigo
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