Progress of radiotherapy combined with anti-PD-1 / PD-L1 in tumor therapy / 国际肿瘤学杂志

ABSTRACT

Radiotherapy is widely used in local treatment of tumors. It can not only directly kill tumor cells by damaging DNA,but also have a great impact on the immune system of the body. This effect is not only inhibited,but also more activated. Programmed death-1(PD-1)and its ligand 1(PD-L1)antibody,as the most popular immune checkpoint inhibitor,can inhibit tumor growth by restoring and enhancing the immune killing function of T cells. With the deepening of the study,it is found that the combination of the two treatment of tumor,the curative effect is better than the single mode.