Intestinal barrier and intestinal endotoxemia / 中国小儿急救医学

ABSTRACT

Intestinal dysfunction can be induced under infection,trauma or stress. The intestinal mu-cosal barrier injury is a common pathophysiological process in critically ill patients. The bowel is one of the earliest and most severely affected organ under severe infection and tissue hypoxia-ischemia. Intestinal dam-age leads to a large number of bacterial flora shift,resulting in intestinal infection,intestinal endotoxemia and intestinal sepsis. In recent years,gastrointestinal barrier function has attracted people′ s attention,which is closely related to the prognosis of critically ill patients. This article described the normal intestinal barrier function,the effects of trauma and stress on intestinal barrier function,bacterial group migration,and the effects of endotoxin translocation on the body and its prevention and treatment.