Clinical significance of inflammatory factors, vascular endothelial function and blood lipid levels in patients with unstable angina pectoris / 中国基层医药

ABSTRACT

Objective To investigate the changes of inflammatory factors,vascular endothelial function and blood lipid in patients with unstable angina pectoris.Methods From March 2017 to March 2018,270 patients with unstable angina pectoris treated in Taizhou Central Hospital were selected as the observation group,and 100 healthy persons from March 2017 to March 2018 were selected as the control group.The contents of CRP,IL-6 and TNF-alpha were determined by enzyme linked immunosorbent assay (ELISA).The content of ET-1 was measured by radioimmunoassay.The content of NO was determined by the method of nitric acid reduction.The contment of blood lipid was measured by automatic biochemical analyzer.The contents of four items of blood lipid were determined by automatic biochemical analyzer.Results The levels of serum CRP[(6.07 ± 1.25) mg/L],IL-6 [(10.42 ± 2.56) mg/L] and TNF-alpha[(3.24 ±0.58) mg/L] in the observation group were higher than those in the control group[(1.04 ± 0.32) mg/L,(2.79 ±0.78) mg/L,(1.16 ±0.34) mg/L] (t =39.729,29.283,33.760,all P ＜0.05).The level of ET-1 in the observation group was (126.42 ±20.91)ng/L,which was higher than that in the control group[(68.93 ± 8.79) ng/L] (t =26.619,P ＜ 0.05),while the level of NO in the observation group [(40.38 ± 7.65) μmol/L] was lower than that in the control group [(67.42 ± 10.42) μmol/L] (t =27.224,P ＜ 0.05).The levels of TC [(5.63 ±0.84) mmol/L],LDL-C [(3.78 ± 0.81) mmol/L] and TG [(1.39 ± 0.29) mmol/L] in the observation group were higher than those in the control group [(4.10 ± 0.65)mtmol/L,(2.19 ± 0.42)mmol/L and (0.65 + 0.12) mmol/L],and the level of HDL-C in the observation group[(1.10 ± 0.21) mmol/L] was lower than that in the control group [(1.49 ± 0.17) mmol/L] (P ＜ 0.05).Conclusion Patients with unstable angina pectoris have obvious inflammatory reaction,vascular endothelial dysfunction and dyslipidemia.It is believed that inflammatory reaction,vascular endothelial function and blood lipid are closely related to the occurrence and development of unstable angina pectoris of coronary heart disease.It is worthy of clinical reference.