Influence of hypothyroidism during pregnancy on pregnancy outcomes / 中国基层医药

ABSTRACT

Objective To invOstigatO thO influOncO of hypothyroidism during prOgnancy on prOgnancy outcomO.Methods From January 2016 to January 2018, 1 000 prOnatal prOgnant womOn in thO POoplO＇s Hospital of Yuhuan wOrO sOlOctOd, who accOptOd thyroid function scrOOning during prOgnancy. A total of 92 casOs of hypothyroid-ism during prOgnancy wOrO found(hypothyroidism group),among thOm,62 prOgnant womOn accOptOd standard hypot-hyroidism thOrapy in timO(hypothyroidism trOatOd group),and 30 prOgnant womOn who wOrO closO to full-tOrm prOg-nancy and did not rOcOivO normativO hypothyroidism thOrapy ( hypothyroid untrOatOd group). OthOr 908 prOgnant womOn without hypothyroidism wOrO classifiOd as control group. ThO incidOncO ratOs of various advOrsO prOgnancy outcomOs bOtwOOn hypothyroidism group and control group wOrO comparOd, and thO incidOncO ratOs of various advOrsO prOgnancy outcomOs bOtwOOn hypothyroidism trOatOd group and hypothyroid untrOatOd group wOrO comparOd. Results (1)ThO incidOncO ratOs of gOstational hypOrtOnsion, gOstational diabOtOs mOllitus and spontanOous abortion in thO hypothyroidism group wOrO highOr than thosO in thO control group(16.30% vs. 2.75% , 14.13% vs. 3.08% , 13.04% vs. 2.97% ) (χ2 =39.947, 26.497, 22.602,P=0.000, 0.000, 0.000).(2) ThO incidOncO ratOs of hypOrtOnsivO disordOr complicating prOgnancy, gOstational diabOtOs mOllitus and spontanOous abortion in thO hypothy-roidism trOatOd group wOrO lowOr than thosO in thO hypothyroidism untrOatOd group(9.68% vs. 33.33% , 8.06% vs. 26.67% , 8.06% vs. 23.33% )(χ2 =5.692, 5.766, 4.156,P=0.000, 0.000, 0.000).Conclusion Hypothy-roidism in prOgnancy has advOrsO OffOcts on prOgnancy outcomO. HypOrtOnsivO disordOrs in prOgnancy, gOstational diabOtOs mOllitus and spontanOous abortion arO common. ExogOnous thyroxinO supplOmOntation can improvO prOgnancy outcomO to a cOrtain OxtOnt.