Analysis of C-reactive protein, fibrinogen and erythrocyte sedimentation rate in patients with obstructive sleep apnea hypopnea syndrome / 中国基层医药

ABSTRACT

Objective To investigate the changes of C-reactive protein (CRP),fibrinogen (FIB) and erythrocyte sedimentation rate (ESR) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS),and their relationship with sleep respiratory parameters.Methods From June 2015 to August 2018,70 OSAHS patients [observation group,apnea hypopnea index (AHI) ≥ 5/h] and 20 persons in the snoring control group (control group,AHI ＜ 5/h) who received the monitor of polysomnography in the Pingxiang People's Hospital were enrolled.The levels of CRP,FIB and ESR were measured and compared between the two groups.The correlations were analyzed between the levels of inflammatory markers and sleep breathing parameters.Results The two groups had no statistically significant differences in age,gender and BMI(all P ＞ 0.05).The CRP,FIB and ESR of the observation group were (4.5 ± 3.0) mg/L,(3.3 ± 0.9) g/L,(11.4 ± 5.4) mm/h,respectively,which were significantly higher than those of the control group [(2.0 ± 1.5) mg/L,(2.9 ± 0.5) g/L,(7.6 ± 2.6) mm/h] (t =5.12,2.68,4.36,all P ＜ 0.05).The level of CRP was positively correlated with AHI,oxygen desaturation index (ODI) (r =0.285,P ＜ 0.05 and r =0.282,P ＜ 0.05),and negatively correlated with the lowest SaO2 and the average SaO2 (r =-0.257,P ＜ 0.05 and r =-0.259,P ＜ 0.05).The level of FIB was positively correlated with AHI,ODI (r =0.430,P ＜ 0.01 and r =0.311,P ＜0.01),and negatively correlated with the lowest SaO2 (r =-0.287,P ＜0.01).There were no correlations between ESR and sleep breathing parameters.Conclusion The levels of CRP,FIB and ESR are increased in OSAHS patients,and the levels of CRP and FIB are proportional to the severity of OSAHS,suggesting that OSAHS patients has systemic inflammatory response.