Effect of remifentanil combined with propofol on anesthesia in gynecological laparoscopic surgery / 中国基层医药

ABSTRACT

Objective To study the effect of remifentanil combined with propofol target-controlled infusion on anesthesia of gynecological laparoscopic surgery.Methods From August 2016 to August 2018,132 patients who needed to undergo gynecological laparoscopy in the Maternal and Child Health Care Hospital of Qujing were selected.The patients were randomly divided into two groups according to the principle of simple randomization,with 66 cases in each group.The observation group was given.remifentanil combined with propofol administered by target-controlled infusion for anesthesia.The control group were given fentanyl intravenous anesthesia.The clinical efficacy of the two groups was observed.Results The onset time of anesthesia [(1.3 ± 0.3) min],awake time [(5.2 ±1.5) min],anesthesia recovery time [(19.6 ± 5.3) min] and analgesic time [(23.6 ± 3.5) min] in the observation group were all shorter than those in the control group[(3.1 ± 0.6) min,(5.0 ± 3.5) min,(4.06 ± 4.8) min,(48.3 ±4.4) min] (t =12.742,15.102,11.265,12.354,all P ＜ 0.0).At 1 min after hemodynamic intubation,10 min after pneumoperitoneum,30 min after operation and 30min after operation,the heart rate,systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the observation group were (82.38 ± 7.45) times/min,(85.65 ± 8.54) times/min,(77.58 ± 8.65) times/min,(80.12 ± 7.77) times/min,SBP(136.25 ± 20.14) mmHg,(140.36 ± 18.02) mmHg,(129.14 ± 15.24) mmHg,(131.25 ± 16.19) mmHg,DBP(986.45 ± 11.02) mmHg,(86.59 ± 10.11) mmHg,(80.17 ± 8.29)mmHg,(82.52 ± 8.17)mmHg,which were better than those in the control group[herat rate(88.14 ± 10.01) times/min,(95.36 ± 8.48) times/min,(86.58 ± 7.33) times/min,(87.48 ± 8.47) times/min;SBP(140.28 ±21.57) mmHg,(144.59 ± 21.35) mmHg,(137.33 ± 18.47) mmHg,(136.25 ± 18.47) mmHg;DBP(90.0 ± 10.14) mmHg,(90.25 ± 11.24) mmHg,(84.25 ± 10.14) mmHg,(82.55 ± 8.84) mmHg] (F =1.320,1.245,1.365,all P ＜ 0.05).Conclusion Remifentanil combined with propofol target controlled infusion for patients undergoing gynecological laparoscopic surgery is helpful to enhance the anesthetic effect,and has a short pharmacodynamic effect,which is conducive to ensuring the quality of surgery.Therefore,it is worthy of popularizing in clinical practice.