Advances in reproductive toxicity of uranium and its mechanism / 局解手术学杂志

ABSTRACT

Objective Uranium, as a heavy metal material, has been used in civil and military activities in China, but it has also caused environmental pollution and human injury.In order to understand and mitigate this injury, scholars studied the damage effect of uranium through building animal models, and found that when uranium enters the animal body, it will accumulate in the body and cause damage to the body, among which the main accumulation organs are kidneys, bones, reproductive organs and so on.Sensitive organs of the role of reproductive organs is uranium, which attracted the attention of the experts, and expand the uranium exposed reproductive toxicity research.They found that the degree of toxicity of uranium is related to the time, dose and mode of uranium exposure, under certain exposure conditions, by changing the sex hormone levels in vivo, the expression of genes or proteins related to the reproductive disorders and excessive produce the mechanism, such as oxidative stress on the toxicity effect, decrease of childbirth pregnant, related to germ cell pathological histology change, and produce genetic reproductive toxicity to the offspring etc., which affect the reproductive system function, damage the health of the body.