Efficacy of multi-sensory stimulation on psychological, behavioral symptoms and health-related quality of life in patients with Alzheimer's disease / 中华行为医学与脑科学杂志

ABSTRACT

Objective To investigate the effects of multisensory stimulation on mental behavioral symptoms and health-related quality of life in patients with Alzheimer's disease (AD).Methods From March 2018 to August 2018,159 AD patients (65-75 years old) in neurology and psychiatric clinic of the Second Affiliated Hospital of Fujian Medical University were enrolled.Randomized grouping was performed by randomized software,experimental group (multi-sensory stimulation),81 cases,control group (no intervention),78 cases.The experimental group had a multi-sensory stimulation for 16 weeks,twice a week,40 minutes each time,for a total of 32 times.At the time of enrollment and 16 weeks after the intervention,the simple neuropsychiatry scale (NPI-Q) and the health-related quality of life questionnaire (HRQLS) were filled out.The t-test and two-factor repeated measures analysis of variance were used to analyze the data.Results The NPI-Q scores of the two groups before and after intervention were compared by two-factor repeated measurement ANOVA.There was no significant difference in NPI-Q average score between the expermental group(2.20±0.22) and control group(2.17±0.35) before intervention (t=0.53,P=0.595).After intervention NPI-Q average score of the experimental group(2.17±0.46) was lower than that of the control group (1.71±0.29) (t =7.56,P＜ 0.01).The intervention effect (F=50.77,P＜ 0.0 1),the time effect (F=39.20,P＜0.01) and interaction effect (F=33.89,P＜0.01) were statistically significant.The HRQLS scores of the two groups before and after intervention were compared by two-factor repeated measurement ANOVA.The intervention effect(F=140.82,P＜0.01),the time effect (F=56.64,P＜0.01) and interaction effect (F=60.38,P＜0.01) were statistically significant.Conclusion Multisensory stimulation can improve mental behavioral symptoms in patients with Alzheimer's disease and improve health-related quality of life.