Regard on the diagnosis and treatment of lethal Anti-NMDAR encephalitis initiated by teratoma / 中国医师杂志

ABSTRACT

Teratoma is the most common germ cell tumor,which accounts for 20％ to 40％ of ovarian tumor.Recently,teratoma has been found to be able to initiate anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis,which belongs to autoimmune encephalitis with the possibilities of lethality and disability.The main clinical features are psychosis,impaired memory,dyskinesia,autonomic dysfunction,seizures,conscious disturbance and central hypoventilation.Most patients can get a good prognosis after immunotherapy and surgery.This article reviews the progresses of anti-NMDAR encephalitis to improve the cognition of clinicians.It is recommended that all anti-NMDAR encephalitis patients should receive tumor screening.And gynecologist should pay more attention to the diagnosis and treatment of benign ovarian tumor.