Clinical study of razumab combined with 25G transconjunctival sutureless vitrectomy in the treatment of 29 patients with idiopathic macular anterior membrane / 中国医师杂志

ABSTRACT

Objective To investigate the effect of razumab combined with 25 G transconjunctival sutureless vitrectomy in patients with idiopathic macular epiretinal membrane (IMEM).Methods 57 cases (57 eyes) of IMEM patients in our hospital were divided into two groups according to random number table.28 cases in the control group were treated with 25G transconjunctival sutureless vitrectomy,and 29 cases in the observation group were treated with rezumab on the basis of the control group.The improvement of visual acuity,changes of macular fovea thickness (central foveal thickness,CFT),serum levels of vascular endothelial growth factor (VEGF) and intercellular adhesion molecule-1 (ICAM-1) in the two groups were observed and compared.The changes of intraocular pressure before treatment and at different time points (1 weeks,1 months,3 months) after treatment and incidence of complications in two groups were statistically analyzed.Results 3 months after treatment,the improvement rate of visual acuity in the observation group was 75.86％ (22/29),higher than that in the control group 50％ (14/28) (P ＜ 0.05).The CFT of the two groups decreased after 3 months of treatment,and the CFT of the observation group was less than that of the control group after 3 months of treatment (P ＜ 0.05).The serum levels of VEGF and ICAM-1 in the observation group were lower than those in the control group 1 week after treatment (P ＜ 0.05).After 1 week of treatment,the intraocular pressure in the observation group was higher than that before treatment,but there was insignificant difference between the two groups.And there was insignificant difference in intraocular pressure between the two groups at 1 and 3 months after treatment (P ＞ 0.05).The incidence of complications in the observation group was 10.34％ (3/29),while that in the control group was 7.14％ (2/28),with no significant difference between the two groups (P ＞ 0.05).Conclusions The combination of rezumab and 25G transconjunctival sutureless vitrectomy can reduce the CFT of IMEM patients,improve their levels of serum ICAM-1 and VEGF,and improve their vision.Besides,it has little influence on intraocular pressure and fewer complications.