Visualization of tumor microenvironment and PET molecular imaging / 中华核医学与分子影像杂志

ABSTRACT

Tumor microenvironment is different from the microenvironment formed by normal cells and surrounding tissues.It is composed of tumor cells,stromal cells,extracellular matrix (ECM),vasculature and various cytokines.Tumor microenvironment can promote the genesis,development,metastasis and resistance to therapy of tumor.Using PET molecular imaging to show tumor microenvironment can provide important biological information for early precise diagnosis and treatment intervention,as well as therapeutic effect evaluation and prognosis of tumor.In this paper,the main application categories and prospects of PET molecular imaging in tumor microenvironment are reviewed.