Tumor acidic microenvironment and targeted pH molecular imaging / 中华核医学与分子影像杂志
Chinese Journal of Nuclear Medicine and Molecular Imaging
;
(6): 300-303, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-745459
ABSTRACT
The tumor acidosis or low extracellular pH (pHe) is a consequence of the anaerobic glycolysis and hypoxia.Tumor acidosis plays a crucial role in tumor progression,metastasis,and resistance to therapy.Recent advances in molecular imaging targeted to tumor acidic microenvironment,including the acido chemical exchange saturation transfer magnetic resonance imaging (AcidoCEST MRI),pH-sensitive nanoparticle and pH-low insertion peptide (pHLIP),offer the opportunity to facilitate the mechanism research in this field and to promote the diagnosis and treatment.This review summarizes the effects of tumor microenvironment on tumor cells and the underlying mechanisms.In addition,this article concentrates more on the application of molecular imaging targeted tumor acidic microenvironment.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Nuclear Medicine and Molecular Imaging
Ano de publicação:
2019
Tipo de documento:
Artigo
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